GM Mosquitoes:
Manipulating a corner of the ecosystem to halt the transmission of Malaria
Related Links and Project References
*Organized by page*
Header Picture and Introduction
0.1: http://animals.nationalgeographic.com/animals/bugs/mosquito/
0.2: Loiseau Cl, et al. First evidence and predictions of Plasmodium transmission in Alaskan bird populations. PLOS ONE. 2012;7:e44729.
0.3: Loiseau Cl, et al. Predictions of avian Plasmodium expansion under climate change. Scientific Reports. 2013;3:1126.
Topic Background
1.1: https://www.youtube.com/watch?v=A2-XTlHBf_4
1.2: https://www.youtube.com/watch?v=Gdv01C74Mq0
1.3: http://www.wired.com/2012/02/gm-mosquitoes/
1.4: http://www.who.int/features/factfiles/malaria/en/
1.5: http://abcnews.go.com/Technology/story?id=5211497
1.6: http://www.who.int/tdr/news/2012/guidance_framework/en/
1.7: http://www.who.int/bulletin/volumes/87/3/09-020309/en/
1.8: http://gamapserver.who.int/mapLibrary/Files/Maps/Endemic_Countries_2012.jpg
1.9: https://www.youtube.com/watch?v=MbXSPacvuak
Technology Timeline
2.1: http://www.cdc.gov/malaria/about/history/ross.html
2.2: Mitchell SW. The literary side of a physician's life-Ronald Ross as a poet. Journal of the American Medical Association. 1907;49:852-853.
2.3: Benedict MQ, Robinson AS. The first release of transgenic mosquitoes: an argument for the sterile insect technique. TRENDS in Parasitology. 2003;19:349-355.
2.4: Catteruccia F, et al. An Anopheles trangenic sexing strain for vector control. Nature Biotechnology. 2005;23:1414-1417.
2.5: Ito J, et al. Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite. Nature. 2002;417:452-455.
2.6: Corby-Harris V, et al. Correction: Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopheles stephensi mosquitoes. 2010;6:e1001003.
2.7: Isaacs AT, et al. Engineered resistance to Plasmodium falciparum development in transgenic Anopheles stephensi. PLoS Pathogens. 2011;7:e1002017.
2.8: Dong Y, et al. Engineered Anopheles immunity to Plasmodium infection. PLoS Pathogens. 2011;7:e1002458.
2.9: Wang S, et al. Fighting malaria with engineered symbiotic bacteria from vector mosquitoes. Proc Natl Acad Sci USA. 2012;109:12734-9.
Biotech Innovators & Economic Impact
3.1: www.oxitec.com
Ethical, Legal, and Social Issues
4.1: http://www.theepochtimes.com/n3/507333-gm-mosquitos-to-be-released-in-Panama-this-weekend/
4.2: http://news.sciencemag.org/2010/11/gm-mosquito-trial-strains-ties-gates-funded-project
4.3: Resnik DB. Ethical issues in field trials of genetically modified disease-resistant mosquitoes. Dev World Bioeth. 2012 Dec 21. Epub ahead of print.
4.4: Marshall JM, et al. Perspectives of people in Mali toward genetically-modified mosquitoes for malaria control. 2010;9:128.